Jaba Tkemaladze

Jaba Tkemaladze
International Longevity Centre - Georgia · Department of Genetics

Doctor of Medicine

About

22
Publications
20,166
Reads
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58
Citations
Introduction
I was born into a family of physicians, therefore I got acquainted with the science of medicine long before my official entry in the field. Over the last 25 years and up to day I have gained hands-on experience with patients of different degrees of health disorders. I have developed the Cytogenetic Theory of Ageing. Relying on my researches and findings I have published a few papers on the study and accomplished clinical trials.
Research Experience
February 2021 - present
International Longevity Centre - Georgia
Position
  • Head of Department
January 2016 - January 2021
International Longevity Centre - Georgia
Position
  • Scientific Researcher
December 2012 - February 2021
Georgia Longevity Alliance
Position
  • CEO
Description
  • Our goal is to create the world where every person can obtain healthy longevity and ageing control through innovative technologies. Our mission is to promote advancement of healthy longevity for all people through scientific research of ageing biology, development of new drugs and therapies, their fast implementation, improvement of public health policy in the field of ageing control, and education.
Education
October 1996 - June 1999
Mikheil Asatiani Psychiatry Research Institute
Field of study
  • Psychiatry Residency Program
September 1989 - May 1995
Tbilisi State Medical University
Field of study
  • General Medicine

Publications

Publications (22)
Article
Full-text available
The centrosome (centriole) and the cytoskeleton produced by it are structures, which probably determine differentiation, morphogenesis, and switching on the mechanism of replicative aging in all somatic cells of multicellular animals. The mechanism of such programming of the events seems to include cytoskeleton influences and small RNAs related to...
Article
Full-text available
Gerontology research carried out in different scientific centers of Georgia follows the basic directions of most work in this field: epidemiology, investigation of the mechanisms of aging, and finding ways to prevent senile pathologies and to prolong life. The genealogy and epidemiology of long-living peaple have been studied in areas with high occ...
Article
Full-text available
A novel RNA was detected in the centrosomes of Spisula solidissima mollusk oocytes in 2006. This RNA was named centrosomal RNA (cnRNA); five different cnRNAs were described. During the sequencing of the first transcript, cnRNA 11, it was discovered that the transcript contained a conserved structure-a reverse transcriptase domain. In a 2005 study,...
Article
Full-text available
Background: Senescent cells are one of the most toxic cells in the human and animal organism. When their amount reaches great quantity, it leads to the strong manifestation of aging signs. According to an explanation of the molecular genetic centriolar theory of aging during the division process cells’ generation reaches ultimate morphogenetic stat...
Article
Full-text available
Irreversible differentiation (change of morphogenetic status) and programmed death (apoptosis) are observed only in somatic cells. Cell division is the only way by which the morphogenetic status of the offspring cells may be modified. It is known that there is a fixed limit to the number of possible cell divisions, the so-called 'Hayflick limit'. E...
Presentation
Full-text available
iCure is a constantly wearable bracelet that detects the earliest signs of an impending disease. The constantly wearable bracelet provides measurements of data storage in real time, consequently automated analysis of such data as temperature, pulse, blood saturation, transdermal fluid (precursor of a sweat) for a complete biochemical analysis. Anal...
Preprint
Full-text available
90% of being healthy depends on what you eat and how you eat So as to be well try not to eat the following All the diary products, milk, yoghurt, farmer cheese, ricotta cheese, condensed milk, kefir, matsoni, dairy cream, etc. Only butter, brined and hard pressed cheese and melted butter are recommended. Fried and boiled skin of chicken and porkl...
Research Proposal
Full-text available
In current times the main task of medicine is to prolong the life expectancy of people and simultaneously improve its quality. Over the last 50 years global average life expectancy has increased for 25 years, the path that was paved owing to modern and laboratory-confirmed diagnoses. However, pandemic COVID-19 has vividly demonstrated the failure o...
Experiment Findings
Full-text available
Participants The experiment included middle aged and elderly men between the ages of 36-60. Average age was 53, 1years. The majority of them led sedentary lifestyle, others were slightly active, some were smokers, some moderately drank alcohol. The participants did not have any specific illnesses that potentially could affect the experiment. These...
Article
Full-text available
Systemic problems pose many challenges in the European healthcare system of the 21st century, and it need strategies that should be implemented as large-scale euro-pilot projects in which monitoring and evaluation of their effectiveness will serve as the main mechanism that generates the sectoral policy of the European healthcare system with an inn...
Article
Full-text available
Antiterrorist management strategies in dense are associated with the methodology of non-biochemical regulation, including for the purpose of technological development of non-biochemical regulation for market-oriented design work on the commercialization of antiterrorist technical means.
Poster
Full-text available
S enescent cells are the last generation of cell differentiation. If programmed cell death (apoptosis) is not activated, then it becomes the main source of intoxication for organism. After 36 years their amount is so great, that signs of aging start strongly manifesting. For many years, scientists try to find combination of substances that could ki...
Conference Paper
Full-text available
Epidemiological data indicate that malignant tumors are rare in schizophrenia patients. Interestingly, the concentration of melatonin, a hormone with anticancer activity, is substantially increased in the blood plasma of schizophrenia patients, whereas its level is reduced in cancer diseases. This however could not fully explain the low cancer inci...
Article
Full-text available
The recent discovery of a new class of RNAs, which are called centrosomal RNAs, in the centrosome is indirect proof of the centrosome hypothesis of cell differentiation and aging, in our opinion. The presence of a reverse transcriptase domain in RNAs of this class and the high specificity of this RNA for the organoid may make the centrosome a site...
Article
Full-text available
In 2006, a group of scientists studying centrosomes of Spisula solidissima mollusc oocytes under the leadership of Alliegro (Alliegro, M.C.; Alliegro, M.A.; Palazzo, R.E. Centrosome-associated RNA in surf clam oocytes. Proc. Natl. Acad. Sci. USA 2006, 103(24), 9034-9038) reliably demonstrated the existence of specific RNA in centrosome, called cent...
Chapter
Full-text available
From the songs of my childhood I can remember one such song: " The cranes are flying far and they will never come back, the rumour is spread ... . " The author of the song text assumes that the cranes can not come back , but he/she can't bear the thought of losing lovely birds and adds: " it's a rumour !" However ,I am saying once more he lets the...
Article
Full-text available
Недавное обнаружение нового класса РНК в центросоме, которая была названа центросомной РНК, по нашему мнению, является косвенным под- тверждением центросомной гипотезы дифферен- циации и старения клеток. Наличие в структуре данного класса РНК домена обратной транскрип- тазы, вместе с ее высокой специфичностью к дан- ному органоиду, возможно, делает...
Conference Paper
Full-text available
Article
Full-text available
Irreversible differentiation (change of morphogenetic status) and programmed death (apoptosis) are observed only in somatic cells, and cell division is the only way by which the morphogenetic status of the offspring cells may be modified. It is known that there is a fixed limit to the number of possible cell divisions, the so-called Hayflick limit....
Conference Paper
Full-text available
https://www.youtube.com/watch?v=aiSrJBjHGYg
Article
Full-text available
Advances in gerontology = Uspekhi gerontologii / Rossiĭskai͡a akademii͡a nauk, Gerontologicheskoe obshchestvo 21(3):367-371 The article is dedicated to analysis of centrosomal hypothesis of cellular aging in the light of new data concerning existence of centrosomal RNA, and also in the light of the role of maternal and daughter centrosomes in proce...
Article
Full-text available
K.N. Chichinadze1, 2, J.V. Tkemaladze1 CENTROSOMAL HYPOTHESIS OF CELLULAR AGING AND IFFERENTIATION 1 Beritashvili Institute of Physiology, 14 ul. Gotua, Tbilisi 0160, Georgia; 2 Tbilisi State University, 1 pr. Chavchavadze, Tbilisi 0128, Georgia; e-mail: [email protected] The article is dedicated to analysis of centrosomal hypothesis of cell...

Questions

Questions (131)

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Projects

Projects (9)
Project
We are studying the possibility of creating a microscope that will allow at least 1 time per second to record the arrangement of atoms in a 1mm cubic space. The cells must remain alive after the scan. And preferably during months of continuous shooting. Processing of these data should give a complete picture of cell nanostructures with a resolution no worse than 9 nucleotides. Ideally, be able to capture more than 1 cell with this microscope. For example, 100 cells is better, 1000 cells are fantastic. Technologies that may guide us - Femto + NMR + Superlight Confocal + Microscope What for Using a microscope, we will shoot a movie about the path of reproductive cells from emergence and maturation to the moment of formation of multicellularity in a new organism. After this movie, we and all other researchers of radical rejuvenation will be able to resolve all the existing controversies about how rejuvenation occurs. And then either put an end to the reproductive line, and this gives freedom of time, or we get 1000 ideas of interventions that can be tested on model species / people. Also, such a microscope can have many alternative uses. Main questions The first priority is wavelength, the second priority is cell survival. It is necessary to understand the minimum wavelength of microscopy, taking into account the survival of the cell. What should be the matrix or film? So far the best candidate is photographic film We need to understand clearly explain the formula - radiation time / wavelength An MRI at a predetermined frequency will take an MRI scan like this. Then a femto scan is done with a confocal microscope using short wave lasers. Are these processes possible? How lenses or mirrors of electromagnetic waves can be controlled. This requires a physicist optician Other questions Is it possible to do this with a stack of the mentioned technologies? What other technologies will be required for implementation? What is the process? What resources and knowledge are needed? How long will it take? How much money will it take for a prototype? How much will 1 picture weigh as a result?
Project
In current times the main task of medicine is to elongate the life expectancy of people and simultaneously improve the quality of life. Over the last 50 years global average life expectancy has increased for 25 years, the path that was paved owing to modern and laboratory-confirmed diagnosis. However, pandemic COVID-19 has vividly demonstrated the failure of existing technologies to duly protect humans from diseases. The weakest point in this matter turned out to be an early recognition of a disease. A prime case in point is detecting the rise of body temperature for a couple of hours during sleep 2 days prior to manifestation of viral disease. It raises an issue to timely detect precursory symptoms of disease long before its full development. The aim of our project is to create mini laboratory clinical tests enclosed in bracelet wearable by man: Icure. The device will monitor the vitals of man around the clock.
Project
Gathering various resources of materials concerning healthy eating in a single file.